Grapefruit Peel Extract Naringenin CAS NO. 10236-47-2

Naringenin Powder is the major flavonoid glycoside in grapefruit and gives grapefruit juice its bitter taste. It is metabolized to the flavanone naringenin in humans.

Both naringin and hesperetin, which are the aglycones of naringin and hesperidin, occur naturally in citrus fruits. Naringin exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of selected drug metabolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug drug interactions in vivo. Ingestion of naringin and related flavonoids can also affect the intestinal absorption of certain drugs, leading to either an increase or decrease in circulating drug levels.



Naringenin Powder Function


1.It has anticancer effect , can kill various cancer cells .

2.It has protective effect on focal cerebral ischemia reperfusion in rats , and its mechanism may relate with its effective scavenging of free radicals. Naringenin significantly decreased the cerebral water content, reduced the volume of cerebral infarction of the impaired brain hemisphere,lowered the level of MDA and improved the activity of SOD in brain. This shows Naringenin can has protective effect on brain hemisphere .

3. This ingredient can significantly lower the plasma cholesterol concentration and the hepatic cholesterol content .

4. The product has also been shown to reduce hepatitis C virus production by infected hepatocytes (liver cells) in cell culture . This seem to be secondary to Narigenin ability to inhibit the secretion of very low density lipoprotein by the cells.

5. It has bioactive effect on human health as antioidant , free radical scavenger , antisepsis , anti-inflammatory , antispasmodic activity.
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